Dual PI3K-δ and PI3K-γ inhibition1
COPIKTRA predominantly targets B cells and disrupts the tumor microenvironment1,2
View dual-isoform PI3K inhibition by clicking through the mechanism of action below.1,2,4,5
PI3K-δ
![](https://copiktrahcp.com/wp-content/uploads/2019/02/icon_bcr-pathway.png)
B-cell receptor (BCR) pathway
BCR signaling promotes cellular growth and proliferation, survival, and migration with involvement from multiple downstream kinases, including the PI3K pathway.
![](https://copiktrahcp.com/wp-content/uploads/2019/02/icon_copiktra.png)
PI3K-δ inhibition with COPIKTRA
PI3K-δ inhibition prohibits proliferation and reduces viability in malignant B cells.
![](https://copiktrahcp.com/wp-content/uploads/2019/02/icon_malignant-b-cell.png)
Malignant B cell
A genetically unstable B cell that inhibits anti-tumorigenic functions while enhancing the functions of other cells to aid in proliferation, survival, and immune evasion.
View dual-isoform PI3K inhibition by clicking through the mechanism of action below. 1,2,6,7
PI3K-γ
![](https://copiktrahcp.com/wp-content/uploads/2019/02/icon_copiktra.png)
PI3K-γ inhibition with COPIKTRA
PI3K-γ inhibition blocks chemokine-mediated T-cell migration and M2 macrophage polarization.
![](https://copiktrahcp.com/wp-content/uploads/2019/02/icon_macrophages.png)
Macrophages
A monocyte lineage that induces BCR signaling, promotes CLL cell survival, and attracts and retains CLL cells.
![](https://copiktrahcp.com/wp-content/uploads/2019/02/icon_mdscs.png)
Myeloid-derived suppressor cells (MDSCs)
A major cell type found in the tumor microenvironment that incites tumor-supportive effects via suppression of immune responses.
![](https://copiktrahcp.com/wp-content/uploads/2019/02/icon_cd4-t-cells.png)
CD4+ T cells
A major cell type that produces pro-survival cytokines and promotes tumor proliferation.
![](https://copiktrahcp.com/wp-content/uploads/2019/02/icon_tumor-microenvironment.png)
Tumor microenvironment
A network of nonneoplastic cells essential to malignant B-cell survival and proliferation.